The OTS is the first international organization to hold a Summit on COVID-19 pandemic at the level of Heads of States on the global scale. At the Summit, the Heads of States put a special emphasis on need of a close cooperation with the WHO.

The OTS has been in close contact with the World Health Organization (WHO) since the outbreak of the pandemic.
Director General of WHO Tedros Adhanom Ghebreyesus delivered a speech at the Extraordinary Video Summit of the OTS held on 10 April 2020. WHO Regional Director for Europe Dr. Hans Kluge also delivered speeches at the Meeting of the Ministers of Health of the OTS on 28 April 2020 and at 4th Meeting of the Health Scientific Group of the Organization on 30 October 2020.
OTS in its turn for the first time participated as a partner at the 70th session of the WHO Regional Committee for Europe on 14 September 2020 and the Secretary General delivered a statement emphasizing support to the proposal of WHO European Regional Office to unite efforts of regional multilateral institutions and mechanisms around health as one of the key objectives of the European Programme of Work (2020–2025) – “United Action for Better Health in Europe”.
The Secretary General and WHO Regional Director with the aim of putting the relations between the two organizations into an institutionalized framework and establishing the legal basis for future engagements signed a Memorandum of Understanding (MOU) on 11 September 2020.
To discuss the cooperation opportunities, as well as to develop an Action Plan between the OTS and WHO on the basis of the MOU signed between the two organizations, the Secretary General visited the Regional Office for Europe of WHO in Copenhagen on 30 November-1 December 2020. 
The parties reaffirmed their determination and solidarity in the fight against COVID-19 pandemic as well as in implementation of the MOU and European Program of Work for 2020–2025.
They also agreed to organize online training programs for health professionals, to accelerate implementation of the International Health Regulation (2005), to improve high vaccination coverage, conduct capacity building for data and health information systems, strengthen digital health in primary health as well as together with the WHO Representatives in the Member and Observer States’s capitals to start procedures of designating new WHO Collaboration Centers.
As a result of the close cooperation between the two organizations, Prof. Dr. Emine Alp Meşe, Deputy Minister of Health of the Republic of Turkey and the Chair of the OTS Health Scientific Group also contributes to the work of the Scientific Advisory Board of the Pan-European Commission on Health and Sustainable Development as the representative of the Organization.
The OTS Secretariat participated in the 72nd session of the WHO Regional Committee for Europe (RC72), on 12–14 September 2022 in Tel Aviv, Israel. The event gathered the Heads of States and Governments, Ministers of health, representatives from 53 countries and international partner organizations across the WHO European Region met first time in-person in three years. In the margins of the RC72nd session, the delegation of the Secretariat and the WHO Europe held meeting to discuss future joint activities and agreed to collaborate on organizing a conference on “Emergency Preparedness and Sustainable Development – shaping our future in a transforming world” in 2023.
Latest meeting between the OTS Secretary General and World Health Organization (WHO) Regional Director for Europe, was held in Copenhagen, Denmark on 28 October 2023 where the parties signed an Action Plan for the implementation of the MoU on cooperation between the two organizations for the term 2024-2025. In line with the Action Plan, two organizations will hold cooperation in strengthening emergency preparedness and response, empowering health systems, ensuring healthy lives and well-being for all and creating an enabling environment for a good partnership. At the meeting also, OTS Secretary General and WHO Europe Director discussed the prospective cooperation opportunities between the OTS and WHO/Europe with the aim to focus on digitalization, capacity building programs, environmentally sustainable health care facilities.